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Yuehai Ke Selected Research

Non-Receptor Type 11 Protein Tyrosine Phosphatase

3/2022Endothelial Shp2 deficiency controls alternative activation of macrophage preventing radiation-induced lung injury through notch signaling.
1/2019Phosphatase Shp2 exacerbates intestinal inflammation by disrupting macrophage responsiveness to interleukin-10.
9/2014Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis.
6/2012Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis.

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Yuehai Ke Research Topics

Disease

12Inflammation (Inflammations)
01/2021 - 06/2012
7Pulmonary Fibrosis (Fibrosing Alveolitis)
01/2022 - 06/2012
7Neoplasms (Cancer)
11/2021 - 07/2010
4Pneumonia (Pneumonitis)
06/2019 - 09/2012
3Lung Injury
03/2022 - 12/2016
3Wounds and Injuries (Trauma)
01/2020 - 11/2016
2Fibrosis (Cirrhosis)
01/2021 - 06/2019
2Lung Neoplasms (Lung Cancer)
10/2020 - 01/2019
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2020 - 01/2019
2Neointima
01/2020 - 12/2019
2Vascular Remodeling
01/2020 - 12/2019
2Asthma (Bronchial Asthma)
11/2016 - 01/2016
2Lymphoma (Lymphomas)
12/2014 - 01/2014
2Carcinogenesis
10/2013 - 07/2010
1Systemic Scleroderma (Systemic Sclerosis)
01/2022
1Acute Lung Injury
12/2021
1Melanoma (Melanoma, Malignant)
01/2021
1Radiation Pneumonitis
10/2020
1Esophageal Neoplasms (Esophageal Cancer)
10/2020
1Vascular System Injuries
01/2020
1Noonan Syndrome (Female Pseudo-Turner Syndrome)
12/2019
1LEOPARD Syndrome (Syndrome, LEOPARD)
12/2019
1Pathologic Processes
06/2019
1Neurodegenerative Diseases (Neurodegenerative Disease)
06/2019
1Respiratory Insufficiency (Respiratory Failure)
06/2019
1Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
06/2019
1Cardiovascular Diseases (Cardiovascular Disease)
03/2019
1Sarcoma (Soft Tissue Sarcoma)
01/2019
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2019
1Memory Disorders (Memory Loss)
11/2017
1Thrombosis (Thrombus)
11/2017
1Pulmonary Emphysema
10/2017
1Emphysema
10/2017
1Autoimmune Diseases (Autoimmune Disease)
01/2017
1Idiopathic Pulmonary Fibrosis
01/2017
1Airway Remodeling
01/2017
1Interstitial Lung Diseases (Interstitial Lung Disease)
12/2016
1Metabolic Syndrome (Dysmetabolic Syndrome X)
10/2016
1Hypersensitivity (Allergy)
12/2014
1Disease Progression
12/2014
1Skin Diseases (Skin Disease)
11/2014
1Contact Dermatitis (Eczema, Contact)
11/2014
1Tuberculosis (Tuberculoses)
10/2014

Drug/Important Bio-Agent (IBA)

10Proteins (Proteins, Gene)FDA Link
01/2021 - 07/2010
8CytokinesIBA
10/2020 - 10/2012
7Tyrosine (L-Tyrosine)FDA Link
11/2017 - 06/2012
5Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2020 - 10/2013
5Protein Tyrosine PhosphatasesIBA
12/2019 - 08/2010
4Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA
03/2022 - 06/2012
4Bleomycin (Blenoxane)FDA LinkGeneric
01/2021 - 09/2014
3EnzymesIBA
12/2021 - 09/2012
3Surface-Active Agents (Surfactants)IBA
01/2017 - 06/2012
2Transforming Growth Factors (Transforming Growth Factor)IBA
01/2021 - 10/2020
2LipopolysaccharidesIBA
01/2020 - 10/2016
2CollagenIBA
12/2019 - 11/2017
2Carrier Proteins (Binding Protein)IBA
01/2019 - 10/2014
2SmokeIBA
01/2017 - 09/2012
2InflammasomesIBA
10/2016 - 10/2016
2Bile Acids and Salts (Bile Acids)IBA
10/2016 - 10/2016
2Biological ProductsIBA
01/2016 - 01/2014
2AntigensIBA
12/2014 - 10/2014
2Interleukin-6 (Interleukin 6)IBA
10/2014 - 10/2013
2Interleukin-22 (IL-22)IBA
10/2012 - 08/2010
1oxidized low density lipoproteinIBA
01/2022
1LDL Receptors (LDL Receptor)IBA
01/2022
1T Cell Transcription Factor 1IBA
11/2021
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2021
1Small Interfering RNA (siRNA)IBA
01/2021
1Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA
01/2021
1Glycoproteins (Glycoprotein)IBA
01/2021
1Reactive Oxygen Species (Oxygen Radicals)IBA
10/2020
1Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2020
1Nitric Oxide Synthase (NO Synthase)IBA
01/2020
1Leucine-Rich Repeat ProteinsIBA
01/2020
1Protein Kinases (Protein Kinase)IBA
01/2020
1Protein Phosphatase 2 (Protein Phosphatase 2A)IBA
06/2019
1N-acetylsphingosineIBA
06/2019
1Phosphoprotein Phosphatases (Phosphatases, Protein)IBA
06/2019
1tanyu tongzhi formulaIBA
03/2019
1Epidermal Growth Factor (EGF)IBA
03/2019
1Interleukin-10 (Interleukin 10)IBA
01/2019
1ferric chlorideIBA
11/2017
1src-Family KinasesIBA
11/2017
1NADPH Oxidases (NAD(P)H oxidase)IBA
11/2017
1Pancreatic Elastase (Elastase)IBA
10/2017
1Matrix Metalloproteinases (MMPs)IBA
10/2017
1AntioxidantsIBA
01/2017
1Interleukin-4 (Interleukin 4)IBA
01/2017
1AllergensIBA
01/2017
1Pharmaceutical PreparationsIBA
11/2016
1aluminum sulfate (alum)IBA
10/2016
1GlucocorticoidsIBA
01/2016
1Immunoglobulin E (IgE)IBA
12/2014
1Phosphotransferases (Kinase)IBA
12/2014
1trichomide AIBA
11/2014
1Picryl Chloride (Trinitrochlorobenzene)IBA
11/2014
1DepsipeptidesIBA
11/2014

Therapy/Procedure

4Therapeutics
11/2021 - 10/2012
2Radiotherapy
03/2022 - 10/2020
2Ligation
01/2020 - 12/2019